Developability refers to the likelihood that an antibody candidate will become a
manufacturable, safe and efficacious drug. Although the safety and efficacy of a drug …

Antibodies are versatile proteins with both the capacity to bind a broad range of targets and
a proven track record as some of the most successful therapeutics. However, the …

Antibodies are proteins produced by the immune system that can identify and neutralise a
wide variety of antigens with high specificity and affinity, and constitute the most successful …

Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals
despite significant challenges and risks to their discovery and development. This review …

Recent advancements in immune sequencing and experimental techniques are generating
extensive T cell receptor (TCR) repertoire data, enabling the development of models to …

Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter
optimization challenge known as “developability”, which reflects an antibody's ability to …

Protein language models (PLMs) learn contextual representations from protein sequences
and are profoundly impacting various scientific disciplines spanning protein design, drug …

Messenger RNA (mRNA) plays a crucial role in protein synthesis, with its codon structure
directly impacting biological properties. While Language Models (LMs) have shown promise …

Monoclonal antibodies (mAbs) are used to prevent, detect, and treat a broad spectrum of
non-communicable and communicable diseases. Over the past few years, the market for …

This perspective sheds light on the transformative impact of recent computational
advancements in the field of protein therapeutics, with a particular focus on the design and …