Metallo-β-lactamases: the quiet before the storm?
The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …
Polysulfides as biologically active ingredients of garlic
U Münchberg, A Anwar, S Mecklenburg… - Organic & biomolecular …, 2007 - pubs.rsc.org
Garlic has long been considered as a natural remedy against a range of human illnesses,
including various bacterial, viral and fungal infections. This kind of antibiotic activity of garlic …
including various bacterial, viral and fungal infections. This kind of antibiotic activity of garlic …
Convenient test for screening metallo-β-lactamase-producing gram-negative bacteria by using thiol compounds
Y Arakawa, N Shibata, K Shibayama… - Journal of clinical …, 2000 - Am Soc Microbiol
ABSTRACT A simple disk diffusion test was constructed for detection of IMP-1-type metallo-β-
lactamase-producing gram-negative bacteria. Two Kirby-Bauer disks containing ceftazidime …
lactamase-producing gram-negative bacteria. Two Kirby-Bauer disks containing ceftazidime …
Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent …
NO Concha, CA Janson, P Rowling, S Pearson… - Biochemistry, 2000 - ACS Publications
Metallo β-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the
hydrolysis of β-lactam antibiotics. This relatively new form of resistance is spreading …
hydrolysis of β-lactam antibiotics. This relatively new form of resistance is spreading …
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase
JH Toney, GG Hammond, PMD Fitzgerald… - Journal of Biological …, 2001 - ASBMB
IMP-1 metallo-β-lactamase (class B) is a plasmid-borne zinc metalloenzyme that efficiently
hydrolyzes β-lactam antibiotics, including carbapenems, rendering them ineffective …
hydrolyzes β-lactam antibiotics, including carbapenems, rendering them ineffective …
Diversity and proliferation of metallo-β-lactamases: a clarion call for clinically effective metallo-β-lactamase inhibitors
The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-
negative bacteria is a serious concern to public health. MBLs are compromising the …
negative bacteria is a serious concern to public health. MBLs are compromising the …
Progress toward inhibitors of metallo-β-lactamases
RP McGeary, DTC Tan, G Schenk - Future Medicinal Chemistry, 2017 - Taylor & Francis
The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …
Thiomandelic Acid, a Broad Spectrum Inhibitor of Zinc β-Lactamases: KINETIC AND SPECTROSCOPIC STUDIES* 210
C Mollard, C Moali, C Papamicael, C Damblon… - Journal of Biological …, 2001 - ASBMB
Resistance to β-lactam antibiotics mediated by metallo-β-lactamases is an increasingly
worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we …
worrying clinical problem. Candidate inhibitors include mercaptocarboxylic acids, and we …
N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase
S Siemann, DP Evanoff, L Marrone… - Antimicrobial agents …, 2002 - Am Soc Microbiol
Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of
IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship …
IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship …
The 1.5-Å structure of Chryseobacterium meningosepticum zinc β-lactamase in complex with the inhibitor, D-captopril
I García-Sáez, J Hopkins, C Papamicael… - Journal of biological …, 2003 - ASBMB
The crystal structure of the class-B β-lactamase, BlaB, from the pathogenic bacterium,
Chryseobacterium meningosepticum, in complex with the inhibitor, d-captopril, has been …
Chryseobacterium meningosepticum, in complex with the inhibitor, d-captopril, has been …