The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis.
Deficient insulin release causes hyperglycemia and diabetes, whereas excessive insulin …

The objective of this study was to determine whether the effects of a fructose diet, which
causes hyperinsulinemia, insulin resistance, and hypertension in male rats, are dependent …

ETHNOPHARMACOLOGICAL RELEVANCE: Solanum torvum (Solanaceae) is a plant used
in Cameroon ethnomedicine for the treatment of hypertension. AIM OF THE STUDY: The …

Fructose feeding induces a rise in blood pressure in normal rats and is associated with
insulin resistance, hyperinsulinemia, and hypertriglyceridemia. We have examined the effect …

Cardiac hypertrophy causes heart failure and is associated with hyperglycemia in patients
with diabetes mellitus. Mibefradil, which acts as a T-type calcium channel blocker, exerts …

ABSTRACT NNC 55‐0396 is a structural analog of mibefradil (Ro 40‐5967) that inhibits
both T‐type and high‐voltage‐activated (HVA) Ca2+ channels with a higher selectivity for T …

Objective In states of insulin resistance, the vasorelaxant actions of insulin are blunted,
which may contribute towards the development of increased vascular tone/hypertension and …

The endothelial actions of insulin remain an area of intense research because they relate to
both insulin sensitivity and vascular tone. Physiological doses of insulin evoke endothelium …

Reports of beneficial, neutral and adverse impacts of antihypertensive drug classes on
glucose and lipid metabolism can be found in human data. Furthermore, mechanisms for …

It has been shown that mibefradil (Ro 40-5967) exerts a selective inhibitory effect on T-type
Ca2+ currents, although at higher concentrations it can antagonize high voltage-activated …