[HTML][HTML] Mechanisms and regulation of replication fork reversal
DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …
human genome per cell division cycle. Replication stress caused by DNA lesions …
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
N Kaminski, AR Wondisford, Y Kwon, ML Lynskey… - Molecular cell, 2022 - cell.com
Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
Insights into the control of RAD51 nucleoprotein filament dynamics from single-molecule studies
F Morati, M Modesti - Current Opinion in Genetics & Development, 2021 - Elsevier
Genomic integrity depends on the RecA/RAD51 protein family. Discovered over five
decades ago with the founder bacterial RecA protein, eukaryotic RAD51 is an ATP …
decades ago with the founder bacterial RecA protein, eukaryotic RAD51 is an ATP …
DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis
Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR),
associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA …
associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA …
Characterization and organization of telomeric-linked helicase (TLH) gene families in Fusarium oxysporum
Telomere-linked RecQ helicase (tlh) genes have been reported in several fungi and a
choanoflagellate in the regions adjacent to the terminal telomere repeats. In this study, we …
choanoflagellate in the regions adjacent to the terminal telomere repeats. In this study, we …
Srs2 and Pif1 as model systems for understanding Sf1a and Sf1b helicase structure and function
Helicases are enzymes that convert the chemical energy stored in ATP into mechanical
work, allowing them to move along and manipulate nucleic acids. The helicase superfamily …
work, allowing them to move along and manipulate nucleic acids. The helicase superfamily …
Mechanistic insights from single-molecule studies of repair of double strand breaks
DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA
damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of …
damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of …
Understanding the Human RECQ5 Helicase—Connecting the Dots from DNA to Clinics
RECQ5, a member of the conserved RECQ helicase family, is the sole human RECQ
homolog that has not been linked to a hereditary developmental syndrome. Nonetheless …
homolog that has not been linked to a hereditary developmental syndrome. Nonetheless …
The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination
V Altmannova, M Spirek, L Orlic, A Jēkabsons… - Iscience, 2022 - cell.com
During meiosis, programmed DNA double-strand breaks (DSBs) are repaired by
homologous recombination. DMC1, a conserved recombinase, plays a central role in this …
homologous recombination. DMC1, a conserved recombinase, plays a central role in this …
RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-
strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the …
strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the …