Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

Adeno-associated virus (AAV) based vectors have emerged as important tools for gene
therapy in humans. The recent successes seen in Phase I/II clinical trials have also …

Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by
providing human cardiomyocytes to support heart regeneration. Studies of human …

Background The pervasive expression of circular RNA is a recently discovered feature of
gene expression in highly diverged eukaryotes, but the functions of most circular RNAs are …

Human pluripotent stem cells (hPSCs) provide a valuable model for the study of human
development and a means to generate a scalable source of cells for therapeutic …

In response to retinal damage, the Müller glial cells (MGs) of the zebrafish retina have the
ability to undergo a cellular reprogramming event in which they enter the cell cycle and …

The four platelet-derived growth factor (PDGF) ligands and PDGF receptors (PDGFRs), α
and β (PDGFRA, PDGFRB), are essential proteins that are expressed during embryonic and …

Vascularization and efficient perfusion are long-standing challenges in cardiac tissue
engineering. Here we report engineered perfusable microvascular constructs, wherein …

Background Maternal smoking is a risk factor for low birth weight and other adverse
developmental outcomes. Objective We sought to determine the impact of standard tobacco …

Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-
like effector nucleases (TALENs), and clustered regularly interspaced short palindromic …