Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Isothermal autocatalytic DNA circuits have been proven to be versatile and powerful
biocomputing platforms by virtue of their self-sustainable and self-accelerating reaction …

Building on our ability to design and synthesise molecules and our understanding of the
noncovalent interactions between these molecules, the chemical sciences are currently …

The design of artificial catalysts able to compete with the catalytic proficiency of enzymes is
an intense subject of research. Non-covalent interactions are thought to be involved in …

The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

Self‐replication is a fundamental concept. The idea of an entity that can repeatedly create
more of itself has captured the imagination of many thinkers from von Neumann to …

Living organisms perform and control complex behaviours by using webs of chemical
reactions organized in precise networks. This powerful system concept, which is at the very …

How new species emerge in nature is still incompletely understood and difficult to study
directly. Self-replicating molecules provide a simple model that allows us to capture the …

Seventy years ago, Erwin Schrodinger posed a profound question:'What is life, and how did
it emerge from non-life?'This problem has puzzled biologists and physical scientists ever …