Lysosome biogenesis: Regulation and functions
C Yang, X Wang - Journal of Cell Biology, 2021 - rupress.org
Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …
cellular homeostasis, development, and aging. Changes in lysosome function are essential …
Structure and function of ER membrane contact sites with other organelles
MJ Phillips, GK Voeltz - Nature reviews Molecular cell biology, 2016 - nature.com
The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have
been studied for decades. The past several years have provided novel insights into the …
been studied for decades. The past several years have provided novel insights into the …
Lysosomal biology and function: modern view of cellular debris bin
PC Trivedi, JJ Bartlett, T Pulinilkunnil - Cells, 2020 - mdpi.com
Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …
Lysosomal physiology
H Xu, D Ren - Annual review of physiology, 2015 - annualreviews.org
Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …
They mediate the degradation of extracellular particles from endocytosis and of intracellular …
Endosome maturation
J Huotari, A Helenius - The EMBO journal, 2011 - embopress.org
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
endocytic processes are linked to almost all aspects of cell life and disease. In this review …
Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification
The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is
essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor …
essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor …
Lysosomal storage disorders: The cellular impact of lysosomal dysfunction
Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …
Membrane repair: mechanisms and pathophysiology
ST Cooper, PL McNeil - Physiological reviews, 2015 - journals.physiology.org
Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …
plasma membrane injuries, including those caused by osmotic stress, by infection from …
The regulation of autophagy by calcium signals: Do we have a consensus?
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
Lysosomes: fusion and function
Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …