Animal models of traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?

S Waldbaum, M Patel - Journal of bioenergetics and biomembranes, 2010 - Springer
Mitochondrial dysfunction and oxidative stress contribute to several neurologic disorders
and have recently been implicated in acquired epilepsies such as temporal lobe epilepsy …

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

A Kondo, K Shahpasand, R Mannix, J Qiu, J Moncaster… - Nature, 2015 - nature.com
Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the
best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's …

The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice

PM Washington, PA Forcelli, T Wilkins… - Journal of …, 2012 - liebertpub.com
Traumatic brain injury (TBI) can cause a broad array of behavioral problems including
cognitive and emotional deficits. Human studies comparing neurobehavioral outcomes after …

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

BD Semple, A Zamani, G Rayner, SR Shultz… - Neurobiology of …, 2019 - Elsevier
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive,
psychological, and psychosocial deficits that can have a profound impact on an individual's …

Concussive brain injury enhances fear learning and excitatory processes in the amygdala

ML Reger, AM Poulos, F Buen, CC Giza, DA Hovda… - Biological …, 2012 - Elsevier
BACKGROUND: Mild traumatic brain injury (cerebral concussion) results in cognitive and
emotional dysfunction. These injuries are a significant risk factor for the development of …

Neuropsychiatric symptom modeling in male and female C57BL/6J mice after experimental traumatic brain injury

LB Tucker, JF Burke, AH Fu, JT McCabe - Journal of neurotrauma, 2017 - liebertpub.com
Psychiatric symptoms such as anxiety and depression are frequent and persistent
complaints following traumatic brain injury (TBI). Modeling these symptoms in animal …

Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury

IP Aisiku, JM Yamal, P Doshi, JS Benoit, S Gopinath… - Critical care, 2016 - Springer
Background Patients with severe traumatic brain injury (TBI) are at risk of the development of
acute respiratory distress syndrome (ARDS). TBI and ARDS pathophysiologic mechanisms …

Psychiatric disorders and health-related quality of life after severe traumatic brain injury: a prospective study

AP Diaz, ML Schwarzbold, ME Thais, A Hohl… - Journal of …, 2012 - liebertpub.com
Traumatic brain injury (TBI) is a major cause of death and disability and impairs health-
related quality of life (HRQOL). Psychiatric disorders have been recognized as major …

Animal models to improve our understanding and treatment of suicidal behavior

TD Gould, P Georgiou, LA Brenner, L Brundin… - Translational …, 2017 - nature.com
Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by
suicide may be preventable, it is well documented that despite major governmental and …