Physics of cell adhesion: some lessons from cell-mimetic systems

E Sackmann, AS Smith - Soft matter, 2014 - pubs.rsc.org
Cell adhesion is a paradigm of the ubiquitous interplay of cell signalling, modulation of
material properties and biological functions of cells. It is controlled by competition of short …

How filopodia pull: what we know about the mechanics and dynamics of filopodia

T Bornschlögl - Cytoskeleton, 2013 - Wiley Online Library
In recent years, the dynamic, hair‐like cell protrusions called filopodia have attracted
considerable attention. They have been found in a multitude of different cell types and are …

Macropinosome formation by tent pole ruffling in macrophages

ND Condon, JM Heddleston, TL Chew, L Luo… - Journal of Cell …, 2018 - rupress.org
Pathogen-mediated activation of macrophages arms innate immune responses that include
enhanced surface ruffling and macropinocytosis for environmental sampling and receptor …

Filopodial retraction force is generated by cortical actin dynamics and controlled by reversible tethering at the tip

T Bornschlögl, S Romero… - Proceedings of the …, 2013 - National Acad Sciences
Filopodia are dynamic, finger-like plasma membrane protrusions that sense the mechanical
and chemical surroundings of the cell. Here, we show in epithelial cells that the dynamics of …

Helical buckling of actin inside filopodia generates traction

N Leijnse, LB Oddershede… - Proceedings of the …, 2015 - National Acad Sciences
Cells can interact with their surroundings via filopodia, which are membrane protrusions that
extend beyond the cell body. Filopodia are essential during dynamic cellular processes like …

Cell cytoskeleton and tether extraction

B Pontes, NB Viana, LT Salgado, M Farina, VM Neto… - Biophysical journal, 2011 - cell.com
We perform a detailed investigation of the force× deformation curve in tether extraction from
3T3 cells by optical tweezers. Contrary to conventional wisdom about tethers extracted from …

Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction

A Padhi, K Singh, J Franco-Barraza, DJ Marston… - Communications …, 2020 - nature.com
Aligned extracellular matrix fibers enable fibroblasts to undergo myofibroblastic activation
and achieve elongated shapes. Activated fibroblasts are able to contract, perpetuating the …

Differential dynamics of platelet contact and spreading

D Lee, KP Fong, MR King, LF Brass, DA Hammer - Biophysical journal, 2012 - cell.com
Platelet spreading is critical for hemostatic plug formation and thrombosis. However, the
detailed dynamics of platelet spreading as a function of receptor-ligand adhesive …

Filopodia rotate and coil by actively generating twist in their actin shaft

N Leijnse, YF Barooji, MR Arastoo, SL Sønder… - Nature …, 2022 - nature.com
Filopodia are actin-rich structures, present on the surface of eukaryotic cells. These
structures play a pivotal role by allowing cells to explore their environment, generate …

An updated look at actin dynamics in filopodia

N Leijnse, LB Oddershede, PM Bendix - Cytoskeleton, 2015 - Wiley Online Library
Cells dynamically interact with and probe their environment by growing finger‐like structures
named filopodia. The dynamics of filopodia are mainly caused by the actin rich core or shaft …