Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue

S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Mesenchymal stem cells: characteristics and clinical applications.

S Bobis, D Jarocha, M Majka - Folia histochemica et …, 2006 - journals.viamedica.pl
Mesenchymal stem cells (MSCs) are bone marrow populating cells, different from
hematopoietic stem cells, which possess an extensive proliferative potential and ability to …

Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells

J Rehman, D Traktuev, J Li, S Merfeld-Clauss… - Circulation, 2004 - Am Heart Assoc
Background—The delivery of autologous cells to increase angiogenesis is emerging as a
treatment option for patients with cardiovascular disease but may be limited by the …

Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart

C Toma, MF Pittenger, KS Cahill, BJ Byrne… - Circulation, 2002 - Am Heart Assoc
Background—Cellular cardiomyoplasty has been proposed as an alternative strategy for
augmenting the function of diseased myocardium. We investigated the potential of human …

Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord

HS Wang, SC Hung, ST Peng, CC Huang, HM Wei… - Stem …, 2004 - academic.oup.com
The Wharton's jelly of the umbilical cord contains mucoid connective tissue and fibroblast‐
like cells. Using flow cytometric analysis, we found that mesenchymal cells isolated from the …

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

AA Mangi, N Noiseux, D Kong, H He, M Rezvani… - Nature medicine, 2003 - nature.com
Transplantation of adult bone marrow–derived mesenchymal stem cells has been proposed
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …

Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction

Y Miyahara, N Nagaya, M Kataoka, B Yanagawa… - Nature medicine, 2006 - nature.com
Mesenchymal stem cells are multipotent cells that can differentiate into cardiomyocytes and
vascular endothelial cells. Here we show, using cell sheet technology, that monolayered …

Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects

JG Shake, PJ Gruber, WA Baumgartner… - The Annals of thoracic …, 2002 - Elsevier
Background. A novel therapeutic option for the treatment of acute myocardial infarction
involves the use of mesenchymal stem cells (MSCs). The purpose of this study was to …

Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis

N Nagaya, T Fujii, T Iwase, H Ohgushi… - American Journal …, 2004 - journals.physiology.org
Mesenchymal stem cells (MSCs) are pluripotent cells that differentiate into a variety of cells,
including cardiomyocytes and endothelial cells. However, little information is available …

Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction

C Gandia, ANA Arminan, JM García-Verdugo… - Stem …, 2008 - academic.oup.com
Human dental pulp contains precursor cells termed dental pulp stem cells (DPSC) that show
self-renewal and multilineage differentiation and also secrete multiple proangiogenic and …