Definition of glaucoma: clinical and experimental concepts

RJ Casson, G Chidlow, JPM Wood… - Clinical & …, 2012 - Wiley Online Library
Glaucoma is a term describing a group of ocular disorders with multi‐factorial etiology united
by a clinically characteristic intraocular pressure‐associated optic neuropathy. It is not a …

Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis

HE Killer, A Pircher - Eye, 2018 - nature.com
Normal tension glaucoma (NTG) is an exception in the “glaucoma family” where the major
risk factor, increased intraocular pressure, is missing. If not increased intraocular pressure …

The eye and the heart

J Flammer, K Konieczka, RM Bruno… - European heart …, 2013 - academic.oup.com
The vasculature of the eye and the heart share several common characteristics. The easily
accessible vessels of the eye are therefore—to some extent—a window to the heart. There is …

The primary vascular dysregulation syndrome: implications for eye diseases

J Flammer, K Konieczka, AJ Flammer - EPMA Journal, 2013 - Springer
Vascular dysregulation refers to the regulation of blood flow that is not adapted to the needs
of the respective tissue. We distinguish primary vascular dysregulation (PVD, formerly called …

Optical coherence tomography angiography macular and peripapillary vessel perfusion density in healthy subjects, glaucoma suspects, and glaucoma patients

G Triolo, A Rabiolo, ND Shemonski… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma
suspects (GS) and glaucoma patients; to correlate ganglion cell–inner plexiform layer …

Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma

Y Miao, GL Zhao, S Cheng, Z Wang, XL Yang - Progress in retinal and eye …, 2023 - Elsevier
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings

MC Leske - Current opinion in ophthalmology, 2009 - journals.lww.com
Current evidence supports the role of vascular factors as part of the multifactorial cause of
OAG. As ocular perfusion pressure reflects the vascular status at the optic disc, it may be …

The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease

JM Sivak - Investigative ophthalmology & visual science, 2013 - iovs.arvojournals.org
Alzheimer's disease (AD) is a common, incurable, and progressive dementia, characterized
by loss of learning and memory and the neuropathologic accumulation of amyloid plaques …

[HTML][HTML] Nitric oxide (NO): an emerging target for the treatment of glaucoma

ME Cavet, JL Vittitow, F Impagnatiello… - … & visual science, 2014 - tvst.arvojournals.org
The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated
via a reduction in aqueous outflow through the conventional (trabecular meshwork and …

Vascular risk factors in glaucoma: a review

M Yanagi, R Kawasaki, JJ Wang… - Clinical & …, 2011 - Wiley Online Library
Glaucoma, one of the major causes of blindness in the world, is a progressive optic
neuropathy. Elevated intraocular pressure is a well‐known major risk factor for glaucoma. In …