G-quadruplexes and helicases
O Mendoza, A Bourdoncle, JB Boulé… - Nucleic acids …, 2016 - academic.oup.com
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …
quadruplexes. These structures may be very stable under physiological conditions …
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
Detection of genomic G-quadruplexes in living cells using a small artificial protein
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …
in essential physiological and pathological processes and serve as important drug targets …
RNA G-quadruplexes: emerging mechanisms in disease
A Cammas, S Millevoi - Nucleic acids research, 2017 - academic.oup.com
Abstract RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
Abstract G-quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which
can enhance or repress gene expression, yet the underlying molecular mechanism remains …
can enhance or repress gene expression, yet the underlying molecular mechanism remains …
Multimodal tetrahedral DNA nanoplatform for surprisingly rapid and significant treatment of acute liver failure
H Wei, K Yi, F Li, D Li, J Yang, R Shi, Y Jin… - Advanced …, 2024 - Wiley Online Library
Acute liver failure (ALF) is a life‐threatening disease associated with the rapid development
of inflammatory storms, level elevation of reactive oxygen species (ROS), and hepatocyte …
of inflammatory storms, level elevation of reactive oxygen species (ROS), and hepatocyte …
Structure and function of multimeric G-quadruplexes
S Kolesnikova, EA Curtis - Molecules, 2019 - mdpi.com
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …
tetrads. They are frequently used as building blocks and functional elements in fields such …
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
C Bruedigam, AH Porter, A Song, G Vroeg in de Wei… - Nature Cancer, 2024 - nature.com
Telomerase enables replicative immortality in most cancers including acute myeloid
leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in …
leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in …
G-quadruplex structures in bacteria: biological relevance and potential as an antimicrobial target
ABSTRACT DNA strands consisting of multiple runs of guanines can adopt a noncanonical,
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …
Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe
The RNA G-quadruplex is an important secondary structure formed by guanine-rich RNA
sequences. However, its folding studies have mainly been studied in vitro. Accurate …
sequences. However, its folding studies have mainly been studied in vitro. Accurate …