Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic
alterations of CD4+ T cells through unclear mechanisms with undefined consequences. We …

Canonical functions of mitochondria include the regulation of cellular survival, orchestration
of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling …

Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are
especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in …

Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes
acute kidney injury (AKI), increases the risk of delayed graft function (DGF), primes the donor …

The liver is a major organ that coordinates the metabolic flexibility of the whole body, which
is characterized by the ability to adapt dynamically in response to fluctuations in energy …

Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may
result in an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …