Is enzyme immobilization a mature discipline? Some critical considerations to capitalize on the benefits of immobilization

JM Bolivar, JM Woodley… - Chemical Society …, 2022 - pubs.rsc.org
Enzyme immobilization has been developing since the 1960s and although many industrial
biocatalytic processes use the technology to improve enzyme performance, still today we …

Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses

AI Benítez-Mateos, D Roura Padrosa, F Paradisi - Nature chemistry, 2022 - nature.com
Enzyme cascades are a powerful technology to develop environmentally friendly and cost-
effective synthetic processes to manufacture drugs, as they couple different …

Enzymes, In Vivo Biocatalysis, and Metabolic Engineering for Enabling a Circular Economy and Sustainability

P Intasian, K Prakinee, A Phintha, D Trisrivirat… - Chemical …, 2021 - ACS Publications
Since the industrial revolution, the rapid growth and development of global industries have
depended largely upon the utilization of coal-derived chemicals, and more recently, the …

The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

Round, round we go–strategies for enzymatic cofactor regeneration

S Mordhorst, JN Andexer - Natural product reports, 2020 - pubs.rsc.org
Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

Putting precision and elegance in enzyme immobilisation with bio-orthogonal chemistry

X Pei, Z Luo, L Qiao, Q Xiao, P Zhang… - Chemical Society …, 2022 - pubs.rsc.org
The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates

SB Ötvös, CO Kappe - Green Chemistry, 2021 - pubs.rsc.org
Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

Artificial photosynthetic cells with biotic–abiotic hybrid energy modules for customized CO2 conversion

F Gao, G Liu, A Chen, Y Hu, H Wang, J Pan… - Nature …, 2023 - nature.com
Programmable artificial photosynthetic cell is the ultimate goal for mimicking natural
photosynthesis, offering tunable product selectivity via reductase selection toward device …

Streamlining design, engineering, and applications of enzymes for sustainable biocatalysis

RA Sheldon, D Brady - ACS Sustainable Chemistry & Engineering, 2021 - ACS Publications
In this Perspective we show how an expansion of the scope and impact of biocatalysis in
industrial organic synthesis is enabled by streamlining the underpinning biocatalyst and …

Flow biocatalysis: A challenging alternative for the synthesis of APIs and natural compounds

M Santi, L Sancineto, V Nascimento… - International journal of …, 2021 - mdpi.com
Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts
in both industry and academia. In the last two decades, the interest in biocatalytic …