Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …

Lysosomes have a critical role in maintaining normal cellular homeostasis mediated by their
involvement in secretion, plasma membrane repair, cell signaling and energy metabolism …

Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically
transported through the Golgi apparatus to the trans-Golgi network, from which transport …

The discovery of the glycosphingolipids is generally attributed to Johan LW Thudichum, who
in 1884 published on the chemical composition of the brain. In his studies he isolated …

In the past decade, our understanding of the role of podocytes in the function of the
glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of …

The aim of this retrospective study was to determine the prevalence of lysosomal storage
disorders (LSDs) in the Czech Republic. The data on cases diagnosed between 1975 and …

It has become increasingly clear that “simple” recessive disorders provide unique insight
into the complexities of common diseases. For years, research on Gaucher disease, a rare …

Vascular endothelial growth factor and its receptors, FLK1/KDR and FLT1, are key
regulators of angiogenesis. Unlike FLK1/KDR, the role of FLT1 has remained elusive. FLT1 …

The lysosomal enzyme glucocerebrosidase, encoded by the glucocerebrosidase gene, is
involved in the breakdown of glucocerebroside into glucose and ceramide. Lysosomal build …

Mutations within the lysosomal enzyme β-glucocerebrosidase (GC) result in Gaucher
disease and represent a major risk factor for developing Parkinson disease (PD). Loss of GC …