Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

A longstanding unsettled question is whether pancreatic β cells originate from exocrine duct
cells. We have now used genetic labeling to fate map embryonic and adult pancreatic duct …

The gastrointestinal tract has a crucial role in the control of energy homeostasis through its
role in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals …

Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

Two major initiatives are under way to correct the β-cell deficit of diabetes: one would
generate β-cells ex vivo that are suitable for transplantation, and the second would stimulate …

FIG. 1. Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated
metallothionen. TGF-transgenic mice have 6% insulin (red, white arrows) cells and some …

Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease that results from cell‐
mediated autoimmune destruction of insulin‐producing cells. In T1DM animal models, it has …

Cell-based therapies offer considerable promise for prevention or cure of diabetes. We
explored the potential of autologous, self-renewing, mesenchymal stem cells (MSC) as a …