An aversive abstinence syndrome manifests 4–24 h following cessation of chronic use of
nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor
expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory …

A large segment of the population suffers from addiction to alcohol, smoking, or illicit drugs.
Not only do substance abuse and addiction pose a threat to health, but the consequences of …

Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …

Hexanucleotide repeat expansions in C9ORF72 are a common cause of familial and
apparently sporadic amyotrophic lateral sclerosis (ALS) and frontal temporal dementia …

Abstract Introduction Some familial Alzheimer's disease (AD) cases are caused by rare and
highly-penetrant mutations in APP, PSEN1, and PSEN2. Mutations in GRN and MAPT, two …

Genetic and functional studies have revealed that both common and rare variants of several
nicotinic acetylcholine receptor subunits are associated with nicotine dependence (ND). In …

Nicotinic acetylcholine receptors are ligand‐gated ion channels that exogenously bind
nicotine. Nicotine produces rewarding effects by interacting with these receptors in the …

Cigarette smoking is the major cause of preventable death and morbidity throughout the
world. Many compounds are present in tobacco, but nicotine is the primary addictive one …