Insulin-like growth factor-binding proteins (IGFBPs) 1–6 bind IGFs but not insulin with high
affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions …

The mouse retina has been used extensively over the past decades to study both
physiologic and pathologic angiogenesis. Over time, various mouse retina models have …

The IGF system plays critical roles in somatic growth in an endocrine fashion (somatomedin
hypothesis) as well as proliferation and differentiation of normal and malignant cells in a …

Cell therapy is a promising option for treating ischemic diseases and heart failure. Adult
stem and progenitor cells from various sources have experimentally been shown to augment …

Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

Purpose.: Because human bone marrow (BM) CD34+ stem cells home into damaged tissue
and may play an important role in tissue repair, this pilot clinical trial explored the safety and …

Angiogenesis is mostly an adaptive response to tissue hypoxia, which occurs under a wide
variety of situations ranging from embryonic development to tumor growth. In general …

Retinal endothelial cells line the arborizing microvasculature that supplies and drains the
neural retina. The anatomical and physiological characteristics of these endothelial cells are …

Calcium phosphate cements (CPC) are currently widely used bone replacement materials
with excellent bioactivity, but have considerable disadvantages like slow degradation. For …

Vessel loss precipitates many diseases. In particular, vessel loss resulting in hypoxia
induces retinal neovascularization in diabetic retinopathy and in retinopathy of prematurity …