Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent
The current pandemic of Covid-19 caused by SARS-CoV-2 is continued to spread globally
and no potential drug or vaccine against it is available. Spike (S) glycoprotein is the …
and no potential drug or vaccine against it is available. Spike (S) glycoprotein is the …
Engineering and expression strategies for optimization of L-Asparaginase development and production
AN Shishparenok, YA Gladilina… - International Journal of …, 2023 - mdpi.com
Genetic engineering for heterologous expression has advanced in recent years. Model
systems such as Escherichia coli, Bacillus subtilis and Pichia pastoris are often used as host …
systems such as Escherichia coli, Bacillus subtilis and Pichia pastoris are often used as host …
In silico modelling and molecular dynamics simulation studies on L-Asparaginase isolated from bacterial endophyte of Ocimum tenuiflorum
Bioactive compounds from endophytes have been used to treat various diseases. In the
present study, L-Asparaginase producing endophytes were isolated from Ocimum …
present study, L-Asparaginase producing endophytes were isolated from Ocimum …
[HTML][HTML] Repurposing FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, and Remdesivir as potential inhibitors against RNA dependent …
Vaccines are undoubtedly the most effective means of combating viral diseases like COVID-
19. However, there are risks associated with vaccination, such as incomplete viral …
19. However, there are risks associated with vaccination, such as incomplete viral …
[HTML][HTML] Can polyoxometalates (POMs) prevent of coronavirus 2019-nCoV cell entry? Interaction of POMs with TMPRSS2 and spike receptor domain complexed with …
N Shahabadi, M Mahdavi, S Zendehcheshm - Informatics in Medicine …, 2022 - Elsevier
The unexpected appearance and global spread of COVID-19 create significant difficulties for
healthcare systems and present an unusual challenge for the fast discovery of medicines to …
healthcare systems and present an unusual challenge for the fast discovery of medicines to …
[HTML][HTML] Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main …
N Shahabadi, S Zendehcheshm, M Mahdavi… - Informatics in Medicine …, 2021 - Elsevier
Abstract By September 1, 2021, SARS-CoV-2, a respiratory virus that prompted Coronavirus
Disease in 2019, had infected approximately 218,567,442 patients and claimed 4,534,151 …
Disease in 2019, had infected approximately 218,567,442 patients and claimed 4,534,151 …
Multi level statistical optimization of l-asparaginase from Bacillus subtilis VUVD001
RR Erva, TC Venkateswarulu, B Pagala - 3 Biotech, 2018 - Springer
Physical and chemical factors influencing the anti-leukemic l-asparaginase enzyme
production by Bacillus subtilis VUVD001 were optimized using multi-stage optimization on …
production by Bacillus subtilis VUVD001 were optimized using multi-stage optimization on …
Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity
AVF Guimarães, NF Frota, MR Lourenzoni - Journal of Molecular Graphics …, 2021 - Elsevier
The l-asparaginase enzyme is used in cancer therapy, mainly acute lymphoid leukemia
(ALL). Commercial enzymes (EcASNase2) cause adverse reactions during treatment, such …
(ALL). Commercial enzymes (EcASNase2) cause adverse reactions during treatment, such …
Screening of potential lead molecule as novel MurE inhibitor: virtual screening, molecular dynamics and in vitro studies
K Zaveri, P Kiranmayi - Current Computer-Aided Drug Design, 2017 - ingentaconnect.com
Background: The prevalence of multi-drug resistance S. aureus is one of the most
challenging tasks for the treatment of nosocomial infections. Proteins and enzymes of …
challenging tasks for the treatment of nosocomial infections. Proteins and enzymes of …
[PDF][PDF] ENHANCING L-ASPARAGINASE CATALYTIC ACTIVITY FOR IMPROVED ANTILEUKEMIC ACTIVITY: A COMPUTATIONAL STUDY ON THERMOCOCCUS …
P EKMEKCİ - 2023 - openaccess.iyte.edu.tr
In this study, thermostable Thermococcus kodakarensis L-asparaginase (TkA) enzyme,
which lacks glutaminase activity, was studied for its structural and dynamic properties. The …
which lacks glutaminase activity, was studied for its structural and dynamic properties. The …