Cancers that appear morphologically similar often have dramatically different clinical
features, respond variably to therapy and have a range of outcomes. Compelling evidence …

Familial pancreatic cancer (FPC) includes those kindreds that contain at least two first-
degree relatives with pancreatic ductal adenocarcinoma. At least 12 known hereditary …

Pancreatic cancer is the fourth leading cause of cancer-related death among men and
women in the United States. A major challenge in treatment remains patients' advanced …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic provide recommendations for genetic testing and counseling for hereditary …

Background Despite improvements in cancer management, most pancreatic cancers are still
diagnosed at an advanced stage. We have recently identified promoter DNA methylation of …

Pancreatic cancer (PC) is one of the most aggressive forms of cancer. Negative prognosis is
mainly due to the late diagnosis in advanced stages, when the disease is already …

Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-
related death and is the most lethal of common malignancies with a five-year survival rate …

Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with
pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes …

The intestinal microenvironment is composed of normal gut microbiota and the environment
in which it lives. The largest microecosystem in the human body is the gut microbiota, which …

Familial pancreatic cancer accounts for 10% of all patients with pancreatic cancer. Because
the 5-year survival rate of pancreatic cancer is only 7%, screening programs for high-risk …