Malaria poses a severe public health risk and a significant economic burden in disease-
endemic countries. One of the most severe issues in malaria control is the development of …

Due to the structure of acylhydrazones both by the pharmacophore–CO–NH–N= group and
by the different substituents present in the molecules of compounds of this class, various …

In an attempt to design and prepare a new library of anticancer candidates, focused
thiopropargylated benzothiazole was reacted with ethyl azidoacetate and/or ethyl …

Objective Sulfanilamide, sulfadiazine, and dapsone were the first sulfonamides to be used to
treat malaria by disrupting the folate biosynthesis process, which is essential for parasite …

Inspired by the role of organotin (IV) compounds as potential pharmaceutical agents, we
have synthesized a series of new diorganotin (IV) complexes (5–20) of hydrazone ligands (1 …

In the current investigation, a new class of quinazolinone N-acetohydrazides 9a-v was
designed as type II multi-kinase inhibitors. The target quinazolinones were tailored so that …

This study presents a synergistic approach encompassing experimental synthesis,
computational analysis, and antioxidant activity evaluation of two aromatic hydrazone …

Malarial parasites have been reported for moderate-high resistance towards classical
antimalarial agents and henceforth development of newer novel chemical entities targeting …

In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …

The present manuscript describes the synthesis, α-amylase inhibition, in silico studies and in-
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …