Domestic dogs are unique from other animal models of cancer in that they generally
experience spontaneous disease. In addition, most types of cancer observed in humans are …

The prevalence of fusions of the transmembrane protease, serine 2, gene (TMPRSS2) with
the erythroblast transformation-specific–related gene (ERG), or TMPRSS2: ERG, in prostate …

Background: Whether the genomic rearrangement transmembrane protease, serine 2
(TMPRSS2): v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic …

Genetic instability, a hallmark feature of human cancers including prostatic
adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations …

To characterize the pattern of ETS rearrangements and to uncover novel ETS fusion genes,
we analyzed 200 prostate carcinomas (PCa) with TaqMan low‐density arrays (TLDAs) …

Prostate cancer is diverse in clinical presentation, histopathological tumor growth patterns,
and survival. Therefore, individual assessment of a tumor's aggressive potential is crucial for …

Genomic rearrangements involving ETS transcription factors are found in 50–70% of
prostate carcinomas. While the large majority of the rearrangements involve ERG, around …

TMPRSS2/ERG fusion is among the most frequent genetic anomalies in prostate
adenocarcinomas. Although positive immunostaining for ERG has been shown to tightly …

Gene fusions involving the erythroblast transformation-specific (ETS) transcription factors
ERG, ETV1, ETV4, ETV5, and FLI1 are a common feature of prostate carcinomas (PCas) …

Purpose: Upregulation of nuclear C-MYC protein has been reported to be an early event in
prostate cancer (PCa); however, its clinicopathological and prognostic significance remain …