Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Proteoglycans have emerged as biomacromolecules with important roles in matrix
remodeling, homeostasis, and signaling in the past two decades. Due to their negatively …

Glypicans are evolutionary conserved, cell surface heparan sulfate (HS) proteoglycans that
are attached to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor …

GPC3 is a proteoglycan involved in the control of proliferation and survival, which has been
linked to several tumor types. In this respect, we previously demonstrated that normal breast …

Breast cancer is the disease with the highest impact on global health, being metastasis the
main cause of death. To metastasize, carcinoma cells must reactivate a latent program …

Abstract Introduction Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in
pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin …

Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal
differentiation. A better understanding of neuroblastoma differentiation is essential for …