Peripheral nerve injury: current challenges, conventional treatment approaches, and new trends in biomaterials-based regenerative strategies

R López-Cebral, J Silva-Correia, RL Reis… - ACS Biomaterials …, 2017 - ACS Publications
Damage to peripheral nerves is a widely extended health problem, causing important
socioeconomic costs worldwide. Indeed, peripheral nerve injuries (PNI) have been …

Gene therapy of chronic limb-threatening ischemia: Vascular medical perspectives

F Simon, M Duran, W Garabet, H Schelzig… - Journal of Clinical …, 2022 - mdpi.com
A decade ago, gene therapy seemed to be a promising approach for the treatment of chronic
limb-threatening ischemia, providing new perspectives for patients without conventional …

Genetically engineered HEK cells as a valuable tool for studying electroporation in excitable cells

T Batista Napotnik, B Kos, T Jarm, D Miklavčič… - Scientific Reports, 2024 - nature.com
Electric pulses used in electroporation-based treatments have been shown to affect the
excitability of muscle and neuronal cells. However, understanding the interplay between …

Characterization of experimentally observed complex interplay between pulse duration, electrical field strength, and cell orientation on electroporation outcome using …

M Scuderi, J Dermol-Černe, T Batista Napotnik… - Biomolecules, 2023 - mdpi.com
Electroporation is a biophysical phenomenon involving an increase in cell membrane
permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently …

Review of developments in bioelectrics as an application of pulsed power technology

RP Joshi, AL Garner… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
The field of bioelectrics lies at the intersection of biomedical engineering, biophysics, pulsed
power technology, and bioscience, guided by the underlying theme of using electric pulses …

Gene transfer by electroporation with high frequency bipolar pulses in vitro

T Potočnik, D Miklavčič, AM Lebar - Bioelectrochemistry, 2021 - Elsevier
High-frequency bipolar pulses (HF-BP) have been demonstrated to be efficient for
membrane permeabilization and irreversible electroporation. Since membrane …

Large animal models of cell-free cardiac regeneration

A Spannbauer, J Mester-Tonczar, D Traxler, N Kastner… - Biomolecules, 2020 - mdpi.com
The adult mammalian heart lacks the ability to sufficiently regenerate itself, leading to the
progressive deterioration of function and heart failure after ischemic injuries such as …

Plasma membrane depolarization and permeabilization due to electric pulses in cell lines of different excitability

J Dermol-Černe, D Miklavčič, M Reberšek, P Mekuč… - …, 2018 - Elsevier
In electroporation-based medical treatments, excitable tissues are treated, either
intentionally (irreversible electroporation of brain cancer, gene electrotransfer or ablation of …

Long-term intake of pasta containing barley (1–3) beta-D-glucan increases neovascularization-mediated cardioprotection through endothelial upregulation of vascular …

V Casieri, M Matteucci, C Cavallini, M Torti, M Torelli… - Scientific Reports, 2017 - nature.com
Abstract Barley (1–3) β-D-Glucan (BBG) enhances angiogenesis. Since pasta is very
effective in providing a BBG-enriched diet, we hypothesized that the intake of pasta …

VEGF serum concentration and irreversible bronchoconstriction in adult asthmatics.

K Gomułka, J Liebhart, U Gładysz… - Advances in Clinical …, 2019 - search.ebscohost.com
Background. Vascular endothelial growth factor (VEGF) is an angiogenic, heparin-binding
glycoprotein playing an important role in the pathogenesis of many diseases and disorders …