Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy
The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …
Integrating micro and nano technologies for cell engineering and analysis: toward the next generation of cell therapy workflows
The emerging field of cell therapy offers the potential to treat and even cure a diverse array
of diseases for which existing interventions are inadequate. Recent advances in micro and …
of diseases for which existing interventions are inadequate. Recent advances in micro and …
Targeting fetal hemoglobin expression to treat β hemoglobinopathies
MH Steinberg - Expert Opinion on Therapeutic Targets, 2022 - Taylor & Francis
Introduction Sickle cell disease and β thalassemia are the principal β hemoglobinopathies.
The complex pathophysiology of sickle cell disease is initiated by sickle hemoglobin …
The complex pathophysiology of sickle cell disease is initiated by sickle hemoglobin …
The dark side of stemness–the role of hematopoietic stem cells in development of blood malignancies
J Filipek-Gorzała, P Kwiecińska, A Szade… - Frontiers in …, 2024 - frontiersin.org
Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism.
However, the high self-renewal and longevity of HSCs predispose them to accumulate …
However, the high self-renewal and longevity of HSCs predispose them to accumulate …