Cytochrome bd oxidase: An emerging anti-tubercular drug target
Cytochrome bd (Cyt-bd) oxidase, one of the two terminal oxidases in the Mycobacterium
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …
A systematic review of economic evaluations of active tuberculosis treatments
Background: The disease burden of active tuberculosis (TB) is considerable, but systematic
reviews of economic evaluations of active TB treatments are scarce. Methods: PubMed …
reviews of economic evaluations of active TB treatments are scarce. Methods: PubMed …
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action …
D Murugesan, PC Ray, T Bayliss… - ACS infectious …, 2018 - ACS Publications
Mycobacterium tuberculosis (MTb) possesses two nonproton pumping type II NADH
dehydrogenase (NDH-2) enzymes which are predicted to be jointly essential for respiratory …
dehydrogenase (NDH-2) enzymes which are predicted to be jointly essential for respiratory …
A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets
LE Via, K England, DM Weiner, D Schimel… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Shortening the lengthy treatment duration for tuberculosis patients is a major goal of current
drug development efforts. The common marmoset develops human-like disease pathology …
drug development efforts. The common marmoset develops human-like disease pathology …
Impact of clofazimine dosing on treatment shortening of the first-line regimen in a mouse model of tuberculosis
NC Ammerman, RV Swanson… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The antileprosy drug clofazimine was recently repurposed as part of a newly endorsed short-
course regimen for multidrug-resistant tuberculosis. It also enables significant treatment …
course regimen for multidrug-resistant tuberculosis. It also enables significant treatment …
Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis
GB Gomez, DW Dowdy, ML Bastos, A Zwerling… - BMC infectious …, 2016 - Springer
Background Despite improvements in treatment success rates for tuberculosis (TB), current
six-month regimen duration remains a challenge for many National TB Programmes, health …
six-month regimen duration remains a challenge for many National TB Programmes, health …
Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial
Background Evidence has existed for decades that higher doses of rifampin may be more
effective, but potentially more toxic, than standard doses used in tuberculosis treatment …
effective, but potentially more toxic, than standard doses used in tuberculosis treatment …
Treatment-shortening effect of a novel regimen combining clofazimine and high-dose rifapentine in pathologically distinct mouse models of tuberculosis
V Saini, NC Ammerman, YS Chang… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Clofazimine and high-dose rifapentine have each separately been associated with treatment-
shortening activity when incorporated into tuberculosis (TB) treatment regimens. We …
shortening activity when incorporated into tuberculosis (TB) treatment regimens. We …
A systematic review of economic evaluations of pharmacological treatments for active tuberculosis
Objectives The continuing spread of tuberculosis (TB) worldwide, especially drug-resistant
TB, poses a major challenge to healthcare systems globally. Addressing this requires …
TB, poses a major challenge to healthcare systems globally. Addressing this requires …
The impact and cost-effectiveness of a four-month regimen for first-line treatment of active tuberculosis in South Africa
Background A 4-month first-line treatment regimen for tuberculosis disease (TB) is expected
to have a direct impact on patient outcomes and societal costs, as well as an indirect impact …
to have a direct impact on patient outcomes and societal costs, as well as an indirect impact …