Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Hereditary fibrinogen abnormalities comprise two classes of plasma fibrinogen defects: Type
I, afibrinogenemia or hypofibrinogenemia, which has absent or low plasma fibrinogen …

Background Effective treatment of trauma-induced coagulopathy is important; however, the
optimal therapy is still not known. We aimed to compare the efficacy of first-line therapy …

Perioperative bleeding is a major challenge particularly because of increasing clinical use of
potent antithrombotic drugs. Understanding current concepts of coagulation is important in …

As our knowledge of the structure and functions of fibrinogen and fibrin has increased
tremendously, several key findings have given some people a superficial impression that the …

Fibrinogen is an abundant plasma protein that, when converted to fibrin by thrombin,
provides the main building blocks for the clot. Dys‐, a‐, and hypo‐fibrinogenemias have …

Background: Thrombin generation is a powerful tool to probe overall plasma coagulability.
Objective: To determine which plasma factors influence the various parameters of the …

Background Normalization of plasma fibrinogen levels may be associated with satisfactory
haemostasis and reduced bleeding. The aim of this retrospective study was to assess …

Congenital fibrinogen disorders are rare diseases affecting either the quantity
(afibrinogenemia and hypofibrinogenemia) or the quality (dysfibrinogenemia) or both …

Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (Aα, Bβ,
and γ), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble …