Synthetic alkylphospholipids (ALPs), such as edelfosine, miltefosine, perifosine,
erucylphosphocholine and erufosine, represent a relatively new class of structurally related …

Lysophosphatidic acid (radyl-glycerol-phosphate, LPA) has captured the interest of lipid
biochemists, cell biologists, physiologists, and physicians alike due to its myriad biological …

Cathelicidins and other antimicrobial peptides are deployed at epithelial surfaces to defend
against infection. These molecules have broad-spectrum killing activity against microbes …

Synthetic anticancer alkylphospholipids (APLs), such as edelfosine, miltefosine and
perifosine, are a group of structurally related lipids that act on cellular membranes rather …

Synthetic ether-linked analogues of phosphatidylcholine and lysophosphatidylcholine,
collectively named as antitumour lipids (ATLs), were initially synthesized in the late 60s, but …

PURPOSE: To increase the therapeutic efficacy of ionizing radiation or to reduce radiation-
mediated side effects, diverse research centers for translational radiation oncology have …

In the last two decades, cellular membranes have been identified as novel targets for
antineoplastic drugs. Two classes of synthetic phospholipid analogues: the …

Perifosine is an Akt inhibitor displaying strong antineoplastic effects in human tumor cell
lines and is currently being tested in phase II clinical trials for treatment of major human …

LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of
cell proliferation, migration and survival. It does so by activating its cognate G-protein …

Many studies have been performed to quantify cell signaling. Cell signaling molecules are
phosphorylated in response to extracellular stimuli, with the phosphorylation sequence …