In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Cellular DNA is susceptible to chemical modifications when exposed to various
environmental agents, chemotherapeutic agents, or endogenous agents produced by …

Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein that is
highly conserved in eukaryotes. RPA plays essential roles in many aspects of nucleic acid …

Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA
and forms 1, 2-d (ApG), 1, 2-d (GpG) and 1, 3-d (GpTpG) intrastrand crosslinks, interstrand …

The cytotoxicity of platinum compounds is thought to be determined primarily by their DNA
adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of adducts …

Publisher Summary DNA damage is a common occurrence that compromises the functional
integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with …

Repair of bulky DNA adducts by the nucleotide excision repair (NER) pathway is one of the
more versatile DNA repair pathways for the removal of DNA lesions. There are two subsets …

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much
progress has been made on elucidating critical roles for RPA in other DNA metabolic …

The development of metal-based antitumor drugs has been stimulated by the clinical
success of cis-diamminedichloroplatinum (II)(cisplatin) and its analogs and by the clinical …