Advancements in the use of platinum complexes as anticancer agents
Background: The platinum (II) complexes as anticancer agents have been well explored for
the development of novel analogs. Yet, none of them achieved clinical importance in …
the development of novel analogs. Yet, none of them achieved clinical importance in …
A promising future of metal‐N‐heterocyclic carbene complexes in medicinal chemistry: The emerging bioorganometallic antitumor agents
Q Zhao, B Han, C Peng, N Zhang… - Medicinal Research …, 2024 - Wiley Online Library
Metal complexes based on N‐heterocyclic carbene (NHC) ligands have emerged as
promising broad‐spectrum antitumor agents in bioorganometallic medicinal chemistry. In …
promising broad‐spectrum antitumor agents in bioorganometallic medicinal chemistry. In …
Glucosyl platinum (II) complexes inhibit aggregation of the C-terminal region of the Aβ peptide
S La Manna, M Leone, I Iacobucci… - Inorganic …, 2022 - ACS Publications
Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence,
many drug discovery processes are oriented to evaluate new compounds that are able to …
many drug discovery processes are oriented to evaluate new compounds that are able to …
Pt (II) versus Pt (IV) in carbene glycoconjugate antitumor agents: Minimal structural variations and great performance changes
Octahedral Pt (IV) complexes (2Pt–R) containing a glycoconjugate carbene ligand were
prepared and fully characterized. These complexes are structural analogues to the trigonal …
prepared and fully characterized. These complexes are structural analogues to the trigonal …
Allyl palladium complexes bearing carbohydrate‐based N‐heterocyclic carbenes: Anticancer agents for selective and potent in vitro cytotoxicity
T Scattolin, E Bortolamiol, F Rizzolio… - Applied …, 2020 - Wiley Online Library
Novel allyl palladium compounds stabilized by carbohydrate‐based N‐heterocyclic
carbenes (NHCs) were prepared and characterized by nuclear magnetic resonance, high …
carbenes (NHCs) were prepared and characterized by nuclear magnetic resonance, high …
Ruthenium complexes bearing glucosyl ligands are able to inhibit the amyloid aggregation of short histidine-peptides
D Florio, S La Manna, A Annunziata, I Iacobucci… - Dalton …, 2023 - pubs.rsc.org
Neurodegenerative diseases are often characterized by the formation of aggregates of
amyloidogenic peptides and proteins, facilitating the formation of neurofibrillary plaques. In …
amyloidogenic peptides and proteins, facilitating the formation of neurofibrillary plaques. In …
Novel fast-acting pyrazole/pyridine-functionalized N-heterocyclic carbene silver complexes assembled with nanoparticles show enhanced safety and efficacy as …
C Chen, L Zhou, B Xie, Y Wang, L Ren, X Chen… - Dalton …, 2020 - pubs.rsc.org
In this study, we designed and synthesized four novel multi-nuclear silver complexes (1–4)
coordinated with pyrazole-or pyridine-functionalized N-heterocyclic carbene (NHC) ligands …
coordinated with pyrazole-or pyridine-functionalized N-heterocyclic carbene (NHC) ligands …
Synthesis and Characterization of Chiral Iridium Complexes Bearing Carbohydrate Functionalized Pyridincarboxamide Ligands and Their Application as Catalysts in …
[Cp* Ir L n Cl] complexes [L 1=(methyl-β-d-glucopyranosid-2-yl) picolinamide, 1; L 2=(methyl-
3, 4, 6-tri-O-acetyl-β-d-glucopyranosid-2-yl) picolinamide, 2; L 3=(2, 3, 4, 6-tetra-O-acetyl-β-d …
3, 4, 6-tri-O-acetyl-β-d-glucopyranosid-2-yl) picolinamide, 2; L 3=(2, 3, 4, 6-tetra-O-acetyl-β-d …
Mixed Arylolefin/NHC Complexes of Platinum(II): Syntheses, Characterizations, and In Vitro Cytotoxicities
Eight platinum (II) complexes of the formula [PtCl (arylolefin)(NHC)](2–9) with varying NHCs
and arylolefin chelators have been prepared and analyzed by spectroscopic and …
and arylolefin chelators have been prepared and analyzed by spectroscopic and …
Halo complexes of gold (i) containing glycoconjugate carbene ligands: Synthesis, characterization, cytotoxicity and interaction with proteins and DNA model systems
New neutral carbene complexes of gold (I)[Au (Im-Me) X](X= Cl, Au1; X= Br, Au2; X= I, Au3)
have been synthesized and fully characterized by different techniques, including NMR and …
have been synthesized and fully characterized by different techniques, including NMR and …