[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
Brain NMDA receptors in schizophrenia and depression
A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …
Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression
Highlights•Chronic stress causes atrophy and decreased connectivity of excitatory neurons
in PFC.•Stress causes disruption of GABAergic inhibitory neurons in the PFC.•GABA …
in PFC.•Stress causes disruption of GABAergic inhibitory neurons in the PFC.•GABA …
Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic …
AL Pehrson, C Sanchez - Drug design, development and therapy, 2015 - Taylor & Francis
Evidence suggesting that central nervous system γ-aminobutyric acid (GABA)
concentrations are reduced in patients with major depressive disorder (MDD) has been …
concentrations are reduced in patients with major depressive disorder (MDD) has been …
GABAergic control of depression-related brain states
B Luscher, T Fuchs - Advances in pharmacology, 2015 - Elsevier
The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced
γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic …
γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic …
M1 acetylcholine receptors in somatostatin interneurons contribute to GABAergic and glutamatergic plasticity in the mPFC and antidepressant-like responses
Alterations in glutamatergic and GABAergic function in the medial prefrontal cortex (mPFC)
are prevalent in individuals with major depressive disorder, resulting in impaired synaptic …
are prevalent in individuals with major depressive disorder, resulting in impaired synaptic …
The change in plasma GABA, glutamine and glutamate levels in fluoxetine-or S-citalopram-treated female patients with major depression
E Küçükibrahimoğlu, MZ Saygın, M Çalışkan… - European journal of …, 2009 - Springer
Objective The aim of this study was to investigate the relationship between plasma
glutamate, glutamine and γ-aminobutyric acid (GABA) levels in female patients with major …
glutamate, glutamine and γ-aminobutyric acid (GABA) levels in female patients with major …
The role of the excitation: inhibition functional balance in the mPFC in the onset of antidepressants
YY Yin, YH Wang, WG Liu, JQ Yao, J Yuan, ZH Li… - …, 2021 - Elsevier
Currently available antidepressants, such as selective serotonin reuptake inhibitors (SSRIs)
and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to …
and serotonin and norepinephrine reuptake inhibitors (SNRIs), generally require weeks to …
Cardamom oil ameliorates behavioral and neuropathological disorders in a rat model of depression induced by reserpine
AA Abdel-Rasoul, NA Saleh, EN Hosny… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Depression is a public health problem. Despite the
availability of treatment options, its prevalence is increasing. A high rate of treatment failure …
availability of treatment options, its prevalence is increasing. A high rate of treatment failure …
A preliminary transcranial magnetic stimulation study of cortical inhibition and excitability in high‐functioning autism and Asperger disorder
PG Enticott, NJ Rinehart, BJ Tonge… - … Medicine & Child …, 2010 - Wiley Online Library
Aim Controversy surrounds the distinction between high‐functioning autism (HFA) and
Asperger disorder, but motor abnormalities are associated features of both conditions. This …
Asperger disorder, but motor abnormalities are associated features of both conditions. This …