Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating
cellular biology at an unprecedented resolution, enabling the characterization of cellular …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

Single-cell omics technologies have revolutionized the study of gene regulation in complex
tissues. A major computational challenge in analyzing these datasets is to project the large …

Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy
insulin-producing beta cells. The aetiology of this complex disease is dependent on the …

Advances in single-cell genomics now enable large-scale comparisons of cell states across
two or more experimental conditions. Numerous statistical tools are available to identify …

The pathophysiology of adverse events following programmed cell death protein 1 (PD-1)
blockade, including tuberculosis (TB) and autoimmunity, remains poorly characterized. We …

Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+ DM) is
an autoimmune condition associated with rapidly progressive interstitial lung disease and …

Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing
functions across cancer types. However, given their short half-life, it remains challenging to …