Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

Novel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell
stem/progenitor cells. However, whether or not adult β cell progenitors exist is one of the …

Cellular progenitors remain poorly characterized in many adult tissues, limited in part by the
lack of unbiased techniques to identify progenitors and their progeny. To address this …

Significant progress has recently been made in our understanding of animal regenerative
biology, spurred on by the use of a wider range of model organisms and an increasing …

The regenerative process in the pancreas is of particular interest because diabetes results
from an inadequate number of insulin-producing beta cells and pancreatic cancer may arise …

In order to generate a zebrafish model of β cell regeneration, we have expressed an
Escherichia coli gene called nfsB in the β cells of embryonic zebrafish. This bacterial gene …

Several recent studies have suggested that the adult bone marrow harbors cells that can
influence β-cell regeneration in diabetic animals. Other reports, however, have contradicted …

FIG. 1. Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated
metallothionen. TGF-transgenic mice have 6% insulin (red, white arrows) cells and some …

The development of insulin-producing pancreatic beta (β)-cells represents the culmination of
a complex developmental program. Cells of the posterior foregut assume a pancreatic …