The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Converging evidence from cellular, electrophysiological, anatomic, and behavioral studies
suggests that the remodeling of synapse structure and function is a critical component of …

Auditory experience during development is necessary for normal language acquisition in
humans. Although songbirds, some cetaceans, and maybe bats may also be vocal learners …

Cyclic adenosine monophosphate (cAMP) is a universal second messenger that plays a
crucial role in diverse biological functions, ranging from transcription to neuronal plasticity …

We developed an IGFBP2-mimetic peptide fragment, JB2, and showed that it promotes
basal synaptic structural and functional plasticity in cultured neurons and mice. We …

Dendrite morphology is pivotal for neural circuitry functioning. While the causative
relationship between small-scale dendrite morphological abnormalities (shape, density of …

Structural plasticity of excitatory synapses is a vital component of neuronal development,
synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory …

The cerebral cortex undergoes rapid folding in an “inside-outside” manner during embryonic
development resulting in the establishment of six discrete cortical layers. This unique …