The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

The value of genome-wide over targeted driver analyses for predicting clinical outcomes of
cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic …

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

During development, progenitors simultaneously activate one lineage while silencing
another, a feature highly regulated in adult stem cells but derailed in cancers. Equipped to …

Chimeric antigen receptor T cells (CAR-Ts) have remarkable efficacy in liquid tumors, but
limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 …

Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal
offspring. This constitutes a major public health concern due to increasing prevalence of …

The immune system encodes information about the severity of a pathogenic threat in the
quantity and type of memory cells it forms. This encoding emerges from lymphocyte …

Delineating gene regulatory networks that orchestrate cell-type specification is a continuing
challenge for developmental biologists. Single-cell analyses offer opportunities to address …

Background The FACT complex is a conserved histone chaperone with critical roles in
transcription and histone deposition. FACT is essential in pluripotent and cancer cells, but …

Helios, a member of the Ikaros family of transcription factors, is predominantly expressed in
developing thymocytes, activated T cells, and regulatory T cells (Tregs). Studies in mice …