Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally
occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer …

In marine adhesives, cation-π interactions play an important role in their liquid-liquid phase
separation process and underlying their strong interfacial bonding. However, it remains …

In this study we expand the accessible dynamic range of single-molecule force spectroscopy
by optical tweezers to the microsecond range by fast sampling. We are able to investigate a …

Force spectroscopy experiments use mechanical force as a control factor to regulate the
folding and unfolding process of proteins. Atomic force microscopy has been widely used to …

Force is increasingly recognized as an important element in controlling biological
processes. Forces are able to deform native protein conformations leading to protein …

The villin headpiece subdomain (HP35) is a fast-folding protein with 35 residues and its
folding pathways have been extensively studied experimentally and theoretically but remain …

In computational drug design, ranking a series of compound analogs in a manner that is
consistent with experimental affinities remains a challenge. In this study, we evaluated the …

Protein collapse from a random chain to the native state involves a dynamical phase
transition. During the process, new scales and collective variables become excited while old …

Ricin is a ribosome-inactivating protein (RIP type 2) consisting of two subunits, ricin toxin A
(RTA) and ricin toxin B (RTB). Because of its cytotoxicity, ricin has worried world authorities …

Infrared (IR) spectroscopy has been widely utilized for the study of protein folding, unfolding,
and misfolding processes. We have previously developed a theoretical method for …