[HTML][HTML] Rationally designed synthetic protein hydrogels with predictable mechanical properties
Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally
occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer …
occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer …
[HTML][HTML] Quantifying cation-π interactions in marine adhesive proteins using single-molecule force spectroscopy
In marine adhesives, cation-π interactions play an important role in their liquid-liquid phase
separation process and underlying their strong interfacial bonding. However, it remains …
separation process and underlying their strong interfacial bonding. However, it remains …
Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy
In this study we expand the accessible dynamic range of single-molecule force spectroscopy
by optical tweezers to the microsecond range by fast sampling. We are able to investigate a …
by optical tweezers to the microsecond range by fast sampling. We are able to investigate a …
[HTML][HTML] Protein folding mechanism revealed by single-molecule force spectroscopy experiments
H Sun, Z Guo, H Hong, P Yu, Z Xue, H Chen - Biophysics Reports, 2021 - ncbi.nlm.nih.gov
Force spectroscopy experiments use mechanical force as a control factor to regulate the
folding and unfolding process of proteins. Atomic force microscopy has been widely used to …
folding and unfolding process of proteins. Atomic force microscopy has been widely used to …
Single Molecule Force Spectroscopy Reveals Force-Enhanced Binding of Calcium Ions by Gelsolin
Force is increasingly recognized as an important element in controlling biological
processes. Forces are able to deform native protein conformations leading to protein …
processes. Forces are able to deform native protein conformations leading to protein …
A novel folding pathway of the villin headpiece subdomain HP35
The villin headpiece subdomain (HP35) is a fast-folding protein with 35 residues and its
folding pathways have been extensively studied experimentally and theoretically but remain …
folding pathways have been extensively studied experimentally and theoretically but remain …
Evaluation of protein–ligand affinity prediction using steered molecular dynamics simulations
N Okimoto, A Suenaga, M Taiji - Journal of Biomolecular Structure …, 2017 - Taylor & Francis
In computational drug design, ranking a series of compound analogs in a manner that is
consistent with experimental affinities remains a challenge. In this study, we evaluated the …
consistent with experimental affinities remains a challenge. In this study, we evaluated the …
Soliton driven relaxation dynamics and protein collapse in the villin headpiece
A Krokhotin, M Lundgren, AJ Niemi… - Journal of Physics …, 2013 - iopscience.iop.org
Protein collapse from a random chain to the native state involves a dynamical phase
transition. During the process, new scales and collective variables become excited while old …
transition. During the process, new scales and collective variables become excited while old …
Determining the relative binding affinity of ricin toxin A inhibitors by using molecular docking and nonequilibrium work
EJF Chaves, IQM Padilha, DAM Araujo… - Journal of Chemical …, 2018 - ACS Publications
Ricin is a ribosome-inactivating protein (RIP type 2) consisting of two subunits, ricin toxin A
(RTA) and ricin toxin B (RTB). Because of its cytotoxicity, ricin has worried world authorities …
(RTA) and ricin toxin B (RTB). Because of its cytotoxicity, ricin has worried world authorities …
Thermally induced protein unfolding probed by isotope-edited IR spectroscopy
L Wang, JL Skinner - The Journal of Physical Chemistry B, 2012 - ACS Publications
Infrared (IR) spectroscopy has been widely utilized for the study of protein folding, unfolding,
and misfolding processes. We have previously developed a theoretical method for …
and misfolding processes. We have previously developed a theoretical method for …