Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

In an ageing society, polypharmacy has become a major public health and economic issue.
Overuse of medications, especially in patients with chronic diseases, carries major health …

Phenoconversion is the mismatch between the individual's genotype-based prediction of
drug metabolism and the true capacity to metabolize drugs due to nongenetic factors. While …

This study provides a whole‐body physiologically‐based pharmacokinetic (PBPK) model of
dextromethorphan and its metabolites dextrorphan and dextrorphan O‐glucuronide for …

Background and Purpose Individualized assessment of cytochrome P450 2D6 (CYP2D6)
activity is usually performed through phenotyping following administration of a probe drug to …

Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical
practice. Typically, drug metabolizing phenotypes are determined based on genetic test …

The cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in
the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter …

Objectives The objective of this study was to establish physiologically based
pharmacokinetic (PBPK) models of tramadol and its active metabolite O‐desmethyltramadol …

The aim of this work was to predict the extent of Cytochrome P450 2D6 (CYP2D6)‐mediated
drug–drug interactions (DDIs) in different CYP2D6 genotypes using physiologically‐based …

Inhibition of a drug-metabolizing enzyme by the reversible interaction of a drug with the
enzyme, thus decreasing the metabolism of another drug, is a major cause of clinically …