Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Insulin and insulin receptors in adipose tissue development

A Cignarelli, VA Genchi, S Perrini… - International journal of …, 2019 - mdpi.com
Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

[HTML][HTML] Effects of intermittent fasting on the circulating levels and circadian rhythms of hormones

BH Kim, Y Joo, MS Kim, HK Choe… - Endocrinology and …, 2021 - synapse.koreamed.org
Intermittent fasting has become an increasingly popular strategy in losing weight and
associated reduction in obesity-related medical complications. Overwhelming studies …

Vaspin in obesity and diabetes: pathophysiological and clinical significance

M Blüher - Endocrine, 2012 - Springer
Vaspin (visceral adipose tissue-derived serpin; serpinA12) was originally identified as an
adipokine, which is predominantly secreted from visceral adipose tissue in Otsuka Long …

Adipose tissue as an endocrine organ

C McGown, A Birerdinc, ZM Younossi - Clinics in liver disease, 2014 - liver.theclinics.com
Obesity is currently one the largest epidemics in the industrialized world. It is also the nexus
on which numerous costly chronic diseases, such as hypertension, hyperlipidemia, T2D …

Role of omentin, vaspin, cardiotrophin-1, TWEAK and NOV/CCN3 in obesity and diabetes development

X Escoté, S Gómez-Zorita, M López-Yoldi… - International journal of …, 2017 - mdpi.com
Adipose tissue releases bioactive mediators called adipokines. This review focuses on the
effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of …

Vaspin inhibits kallikrein 7 by serpin mechanism

JT Heiker, N Klöting, P Kovacs, EB Kuettner… - Cellular and Molecular …, 2013 - Springer
The molecular target of the adipokine vaspin (visceral adipose tissue-derived serpin;
serpinA12) and its mode of action are unknown. Here, we provide the vaspin crystal …

Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects

N Klöting, P Kovacs, M Kern, JT Heiker, M Fasshauer… - Diabetologia, 2011 - Springer
Aims/hypothesis Vaspin (visceral adipose tissue-derived serpin) was first identified as an
adipokine in a rat model of type 2 diabetes, in which it is predominantly secreted from …

Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans

H Yu, F Xia, KSL Lam, Y Wang, Y Bao, J Zhang… - Clinical …, 2011 - academic.oup.com
BACKGROUND Fibroblast growth factor (FGF) 21 is an endocrine factor actively involved in
glucose and lipid metabolism in rodents. However, little is known about its physiological …

The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis

R Dimova, T Tankova - BioMed research international, 2015 - Wiley Online Library
In recent years, most research efforts have been focused on studying insulin‐sensitizing
adipokines. One of the most recently discovered adipokines is vaspin, a visceral adipose …