The expanding utility of iron-sulfur clusters: Their functional roles in biology, synthetic small molecules, maquettes and artificial proteins, biomimetic materials, and …

AE Boncella, ET Sabo, RM Santore, J Carter… - Coordination Chemistry …, 2022 - Elsevier
The ubiquity, structural variation, and functional diversity of iron-sulfur (Fe-S) clusters in
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …

[HTML][HTML] Fe/S proteins in microbial sulfur oxidation

C Kümpel, M Grosser, TS Tanabe, C Dahl - Biochimica et Biophysica Acta …, 2024 - Elsevier
Iron-sulfur clusters serve as indispensable cofactors within proteins across all three domains
of life. Fe/S clusters emerged early during the evolution of life on our planet and the …

Stabilisation of the RirA [4Fe–4S] cluster results in loss of iron-sensing function

E Gray, MYY Stewart, L Hanwell, JC Crack… - Chemical …, 2023 - pubs.rsc.org
RirA is a global iron regulator in diverse Alphaproteobacteria that belongs to the Rrf2
superfamily of transcriptional regulators, which can contain an iron–sulfur (Fe–S) cluster …

Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors

R Rohac, JC Crack, E de Rosny, O Gigarel… - Communications …, 2022 - nature.com
Several transcription factors of the Rrf2 family use an iron-sulfur cluster to regulate DNA
binding through effectors such as nitric oxide (NO), cellular redox status and iron levels.[4Fe …

Modulation of MagR magnetic properties via iron–sulfur cluster binding

Z Guo, S Xu, X Chen, C Wang, P Yang, S Qin… - Scientific Reports, 2021 - nature.com
Iron–sulfur clusters are essential cofactors found in all kingdoms of life and play essential
roles in fundamental processes, including but not limited to respiration, photosynthesis, and …

Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking

DA Capdevila, JJ Rondón, KA Edmonds… - Chemical …, 2024 - ACS Publications
Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Iron–sulfur Rrf2 transcription factors: an emerging versatile platform for sensing stress

R Banerjee, I Askenasy, EL Mettert, PJ Kiley - Current Opinion in …, 2024 - Elsevier
Highlights•Rrf2 transcription factors maintain homeostasis in response to various
stresses.•Many Rrf2 family members utilize Fe-S cluster cofactors in signaling.•Distinct …

Structural insights into the mechanism of the radical SAM carbide synthase NifB, a key nitrogenase cofactor maturating enzyme

AS Fajardo, P Legrand, L Payá-Tormo… - Journal of the …, 2020 - ACS Publications
Nitrogenase is a key player in the global nitrogen cycle, as it catalyzes the reduction of
dinitrogen into ammonia. The active site of the nitrogenase MoFe protein corresponds to a …

Biological iron-sulfur clusters: Mechanistic insights from mass spectrometry

JC Crack, NE Le Brun - Coordination Chemistry Reviews, 2021 - Elsevier
Iron-sulfur (FeS) clusters are protein cofactors that are ubiquitous in life, performing a wide
range of functions, such as in electron transfer, catalysis and gene regulation. This functional …

Sensing mechanisms of iron–sulfur cluster regulatory proteins elucidated using native mass spectrometry

JC Crack, E Gray, NE Le Brun - Dalton Transactions, 2021 - pubs.rsc.org
The ability to sense and respond to various key environmental cues is important for the
survival and adaptability of many bacteria, including pathogens. The particular sensitivity of …