[HTML][HTML] Ankylosing spondylitis: etiology, pathogenesis, and treatments
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
Ankylosing spondylitis risk factors: a systematic literature review
MC Hwang, L Ridley, JD Reveille - Clinical rheumatology, 2021 - Springer
Radiographic axial spondyloarthritis (also known as ankylosing spondylitis [AS]) is a chronic
immune-mediated arthritis characterized by inflammation of the axial skeleton, peripheral …
immune-mediated arthritis characterized by inflammation of the axial skeleton, peripheral …
Autoimmunity-associated T cell receptors recognize HLA-B* 27-bound peptides
Human leucocyte antigen B* 27 (HLA-B* 27) is strongly associated with inflammatory
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …
[HTML][HTML] Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
OV Britanova, KR Lupyr, DB Staroverov, IA Shagina… - Nature Medicine, 2023 - nature.com
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …
at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy …
OLGA: fast computation of generation probabilities of B-and T-cell receptor amino acid sequences and motifs
Motivation High-throughput sequencing of large immune repertoires has enabled the
development of methods to predict the probability of generation by V (D) J recombination of …
development of methods to predict the probability of generation by V (D) J recombination of …
[HTML][HTML] T cell repertoire profiling and the mechanism by which HLA-B27 causes ankylosing spondylitis
J Garrido-Mesa, MA Brown - Current rheumatology reports, 2022 - Springer
Abstract Purpose of Review Ankylosing spondylitis (AS) is strongly associated with the HLA-
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …
[HTML][HTML] Joint together: The etiology and pathogenesis of ankylosing spondylitis
Y Xiong, M Cai, Y Xu, P Dong, H Chen, W He… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) refers to a group of diseases with inflammation in joints and spines.
In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the …
In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the …
[HTML][HTML] Detecting T cell receptors involved in immune responses from single repertoire snapshots
Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …
Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination
Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR)
sequences are found in a large number of individual mice and humans. These widely …
sequences are found in a large number of individual mice and humans. These widely …
Pathophysiology and immunolgical basis of axial spondyloarthritis
MGH van de Sande, D Elewaut - Best Practice & Research Clinical …, 2023 - Elsevier
Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …
technologies greatly advanced the insight into the mechanisms that play an important role in …