The management of intracranial germ-cell tumours is complex because of varied clinical
presentations, tumour sites, treatments and outcomes, and the need for multidisciplinary …

Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …

Background Clinical management of germ cell tumours (GCTs) relies on monitoring of
serum tumour markers. However, the markers α-fetoprotein (AFP), the β-subunit of human …

Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young
adult men and the incidence of these tumours is increasing. Current research priorities in …

Purpose: Classic serum tumor markers (human chorionic gonadotropin, α1-fetoprotein and
lactate dehydrogenase) have an important role in managing testicular germ cell tumor …

Testicular germ cell tumours (TGCTs) are the most frequent cancer type in young men and
originate from the common precursor germ cell neoplasia in situ (GCNIS). For decades …

Liquid biopsy-based biomarkers, such as microRNAs, represent valuable tools for patient
management, but often do not make it to integration in the clinic. We aim to explore issues …

Background: The current biomarkers alpha-fetoprotein and human chorionic gonadotropin
have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs) …

Background: miRNAs are small noncoding RNA molecules that can be released into body
fluids. Germ cell tumours (GCTs) overexpress miRNAs of the miR-371-3 cluster. Thus, serum …

Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males.
GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal …