Reactive oxygen species in cancer: Current findings and future directions

H Nakamura, K Takada - Cancer science, 2021 - Wiley Online Library
Reactive oxygen species (ROS), a class of highly bioactive molecules, have been widely
studied in various types of cancers. ROS are considered to be normal byproducts of …

[HTML][HTML] EMT, cancer stem cells and autophagy; The three main axes of metastasis

G Babaei, SGG Aziz, NZZ Jaghi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

Intermittent fasting in the prevention and treatment of cancer

KK Clifton, CX Ma, L Fontana… - CA: a cancer journal for …, 2021 - Wiley Online Library
Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

ME Bahar, HJ Kim, DR Kim - Signal transduction and targeted therapy, 2023 - nature.com
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Mechanism of interaction between autophagy and apoptosis in cancer

S Das, N Shukla, SS Singh, S Kushwaha… - Apoptosis, 2021 - Springer
The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Tumour treating fields therapy for glioblastoma: current advances and future directions

O Rominiyi, A Vanderlinden, SJ Clenton… - British journal of …, 2021 - nature.com
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and
continues to portend poor survival, despite multimodal treatment using surgery and …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Metabolic reprogramming in cholangiocarcinoma

C Raggi, ML Taddei, C Rae, C Braconi, F Marra - Journal of hepatology, 2022 - Elsevier
Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the
increased energy demands required for rapid proliferation, invasion, and metastasis …

The regulation of ferroptosis by tumor suppressor p53 and its pathway

J Liu, C Zhang, J Wang, W Hu, Z Feng - International journal of molecular …, 2020 - mdpi.com
Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …

Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases

GD Albano, RP Gagliardo, AM Montalbano, M Profita - Antioxidants, 2022 - mdpi.com
Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …