DNA vaccines: ready for prime time?
MA Kutzler, DB Weiner - Nature Reviews Genetics, 2008 - nature.com
Since the discovery, over a decade and a half ago, that genetically engineered DNA can be
delivered in vaccine form and elicit an immune response, there has been much progress in …
delivered in vaccine form and elicit an immune response, there has been much progress in …
Vaccines for tumour prevention
Despite tremendous progress in basic and epidemiological research, effective prevention of
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …
Phosphoinositide 3-kinase gamma inhibition protects from anthracycline cardiotoxicity and reduces tumor growth
Background: Anthracyclines, such as doxorubicin (DOX), are potent anticancer agents for
the treatment of solid tumors and hematologic malignancies. However, their clinical use is …
the treatment of solid tumors and hematologic malignancies. However, their clinical use is …
Zoledronic acid repolarizes tumour‐associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway
It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against
tumours not located in bone. Mice transgenic for the activated ErbB‐2 oncogene were …
tumours not located in bone. Mice transgenic for the activated ErbB‐2 oncogene were …
Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques
A Luckay, MK Sidhu, R Kjeken, S Megati… - Journal of …, 2007 - Am Soc Microbiol
Since human immunodeficiency virus (HIV)-specific cell-mediated immune (CMI) responses
are critical in the early control and resolution of HIV infection and correlate with …
are critical in the early control and resolution of HIV infection and correlate with …
[PDF][PDF] Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model
CP Chang, MC Yang, HS Liu, YS Lin, HY Lei - Hepatology, 2007 - Wiley Online Library
Concanavalin A (ConA), a lectin with mannose specificity that can induce acute hepatic
inflammation, was tested for its therapeutic effect against hepatoma. ConA is cytotoxic or …
inflammation, was tested for its therapeutic effect against hepatoma. ConA is cytotoxic or …
Oncogenic protein tyrosine kinases: Role of HER2/neu in tumor progression and therapy
S Menard, P Casalini, M Campiglio, SM Pupa… - Cellular and Molecular …, 2004 - Springer
HER2 (human epidermal growth factor receptor-2; also known as erbB2) and its relatives
HER1 (epidermal growth factor receptor; EGFR), HER3 and HER4 belong to the HER family …
HER1 (epidermal growth factor receptor; EGFR), HER3 and HER4 belong to the HER family …
Mitotic spindle assembly and genomic stability in breast cancer require PI3K-C2α scaffolding function
Proper organization of the mitotic spindle is key to genetic stability, but molecular
components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still …
components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still …
Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases
GJ Prud'homme, Y Glinka, AS Khan… - Current Gene …, 2006 - ingentaconnect.com
Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation
(also denoted electrogene transfer or electrokinetic enhancement). This approach is safe …
(also denoted electrogene transfer or electrokinetic enhancement). This approach is safe …
Electroporation for targeted gene transfer
The utilisation of nonviral gene delivery methods has been increasing st-eadily, however, a
drawback has been the relative low efficiency of gene transfer with naked DNA compared …
drawback has been the relative low efficiency of gene transfer with naked DNA compared …