The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …

The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid,
selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of …

Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …

Significance: Iron-dependent lipid peroxidation is a complex oxidative process where
phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …

The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …