Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …

The central and peripheral nervous systems play critical roles in regulating pancreatic islet
function and glucose metabolism. Over the last century, in vitro and in vivo studies along …

Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic
ganglia. Intrapancreatic ganglia constitute a complex information-processing center that …

In the last 10 years, several studies have shown that the pancreas of patients with type 1
diabetes (T1D), and even of subjects at risk for T1D, was smaller than the pancreas from …

The autonomic nervous system regulates pancreatic function. Islet capillaries are essential
for the extension of axonal projections into islets, and both of these structures are important …

The histological analysis of human pancreatic samples in type 1 diabetes (T1D) has been
proven essential to move forward in the evaluation of in situ events characterizing T1D …

Abstract Purpose of Review Type 1 diabetes (T1D) is one of the most frequent chronic
autoimmune diseases in humans, characterized by the lack of insulin production resulting in …

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Background The sympathetic nervous system plays an important role in the regulation of
pancreatic exocrine and endocrine secretion. The results of experimental studies also …

Aims/hypothesis Compromised pancreatic sympathetic innervation has been suggested as
a factor involved in both immune-mediated beta cell destruction and endocrine …