Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …

Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

Ferroptosis is a form of programmed cell death characterized by intracellular iron
accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 …

Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth
and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells …

The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …

Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …

ATP is required for mammalian cells to remain viable and to perform genetically
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …

Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis
pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In …