Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the
haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly …

The expression profiles and spatial distributions of RNAs regulate many cellular functions.
Image-based transcriptomic approaches provide powerful means to measure both …

An important function of microtubules is to move cellular structures such as chromosomes,
mitotic spindles and other organelles around inside cells. This is achieved by attaching the …

Most solid tumors are aneuploid, and it has been proposed that aneuploidy is the
consequence of an elevated rate of chromosome missegregation in a process called …

Using in vitro assays with purified proteins, we show that XKCM1 and XKIF2, two distinct
members of the internal catalytic domain (Kin I) kinesin subfamily, catalytically destabilize …

Most solid tumours are aneuploid and many frequently mis-segregate chromosomes. This
chromosomal instability is commonly caused by persistent mal-oriented attachment of …

Genome instability is a hallmark of cancer cells. Chromosome instability (CIN), which is often
mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome …