Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization
Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …
Engineering a rugged nanoscaffold to enhance plug-and-display vaccination
Nanoscale organization is crucial to stimulating an immune response. Using self-
assembling proteins as multimerization platforms provides a safe and immunogenic system …
assembling proteins as multimerization platforms provides a safe and immunogenic system …
Pathophysiology and neurologic sequelae of cerebral malaria
N Schiess, A Villabona-Rueda, KE Cottier, K Huether… - Malaria journal, 2020 - Springer
Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …
The structural basis for CD36 binding by the malaria parasite
CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …
Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …
the world's population at risk of Plasmodium infections. The development of an effective …
Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
Malaria is among the most serious infectious diseases affecting humans, accounting for
approximately half a million deaths each year. Plasmodium falciparum causes most life …
approximately half a million deaths each year. Plasmodium falciparum causes most life …
PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis
L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …