Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

KD Brune, DB Leneghan, IJ Brian, AS Ishizuka… - Scientific reports, 2016 - nature.com
Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …

Engineering a rugged nanoscaffold to enhance plug-and-display vaccination

TUJ Bruun, AMC Andersson, SJ Draper, M Howarth - ACS nano, 2018 - ACS Publications
Nanoscale organization is crucial to stimulating an immune response. Using self-
assembling proteins as multimerization platforms provides a safe and immunogenic system …

Pathophysiology and neurologic sequelae of cerebral malaria

N Schiess, A Villabona-Rueda, KE Cottier, K Huether… - Malaria journal, 2020 - Springer
Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …

The structural basis for CD36 binding by the malaria parasite

FL Hsieh, L Turner, JR Bolla, CV Robinson… - Nature …, 2016 - nature.com
CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …

Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

F Saito, K Hirayasu, T Satoh, CW Wang, J Lusingu… - Nature, 2017 - nature.com
Malaria is among the most serious infectious diseases affecting humans, accounting for
approximately half a million deaths each year. Plasmodium falciparum causes most life …

PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …