High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

For more than 50 years, evidence has accumulated that inflammation contributes to the
pathogenesis of hypertension. Immune cells have been observed in vessels and kidneys of …

Inflammation is essential in the initial development and progression of many cardiovascular
diseases involving innate and adaptive immune responses. The role of CD4+ CD25+ …

Transforming growth factor–β (TGF-β) is a major immunosuppressive cytokine that maintains
immune homeostasis and prevents autoimmunity through its antiproliferative and anti …

Sodium accumulates in the interstitium and promotes inflammation through poorly defined
mechanisms. We describe a pathway by which sodium enters dendritic cells (DCs) through …

Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

Aims Elevated levels of pro-inflammatory cytokine interleukin-17A (IL-17) are associated
with hypertensive autoimmune diseases; however, the connection between IL-17 and …

In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers
that reliably track kidney injury, demonstrate treatment-response, and predict outcomes …

The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with
contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo …

Objective—We previously demonstrated that a reduced number of CD4+ CD25+-regulatory
T cells (Tregs) was associated with microvascular dysfunction in hypertension. However, the …