[HTML][HTML] Advances in aptameric biosensors designed to detect toxic contaminants from food, water, human fluids, and the environment
Detection of toxic small molecule contaminants with sensitivity, accuracy, and specificity is a
challenging task. Traditionally used HPLC and mass spectrometry-based assays suffer from …
challenging task. Traditionally used HPLC and mass spectrometry-based assays suffer from …
Spatial imaging of glycoRNA in single cells with ARPLA
Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …
discovered class of glycosylated molecules, because of a lack of visualization methods. We …
Advances of aptamer-based small-molecules sensors in body fluids detection
L Chen, G Yang, F Qu - Talanta, 2024 - Elsevier
The field of aptamer-based sensing has evolved considerably over the past three decades.
The aptamer sensor-based detection of small-molecule targets in body fluids is designed for …
The aptamer sensor-based detection of small-molecule targets in body fluids is designed for …
Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications
Nowadays, there is a high demand for sensitive and selective real-time analytical methods
suitable for a wide range of applications, from personalized telemedicine, drug discovery …
suitable for a wide range of applications, from personalized telemedicine, drug discovery …
Systematic Study of in Vitro Selection Stringency Reveals How To Enrich High-Affinity Aptamers
O Alkhamis, Y Xiao - Journal of the American Chemical Society, 2022 - ACS Publications
Aptamers are oligonucleotide receptors with great potential for sensing and therapeutic
applications. They are isolated from random libraries through an in vitro method termed …
applications. They are isolated from random libraries through an in vitro method termed …
Development of novel fluorescence-based and label-free noncanonical G4-quadruplex-like DNA biosensor for facile, specific, and ultrasensitive detection of fipronil
Fipronil is a broad-spectrum insecticide widely used in agriculture and residential areas; its
indiscriminate use leads to environmental pollution and poses health hazards. Early …
indiscriminate use leads to environmental pollution and poses health hazards. Early …
A novel biosensing platform for detection of glaucoma biomarker GDF15 via an integrated BLI-ELASA strategy
S Gao, Q Li, S Zhang, X Sun, H Zhou, Z Wang, J Wu - Biomaterials, 2023 - Elsevier
Highlights•An aptamer with high affinity, high specificity, and high stability for binding to both
human-derived and rat-derived GDF15 was obtained.• The molecular mechanism and key …
human-derived and rat-derived GDF15 was obtained.• The molecular mechanism and key …
[HTML][HTML] Identification and structural analysis of novel malathion-specific DNA aptameric sensors designed for food testing
Malathion is an organophosphate chemical (OPC) and a toxic contaminant that adversely
impacts food quality, human health, biodiversity, and the environment. Due to its small size …
impacts food quality, human health, biodiversity, and the environment. Due to its small size …
Nuclease-assisted selection of slow-off rate aptamers
Conventional directed evolution methods offer the ability to select bioreceptors with high
binding affinity for a specific target in terms of thermodynamic properties. However, there is a …
binding affinity for a specific target in terms of thermodynamic properties. However, there is a …
Aptamer‐Assisted Blockade of the Immune Suppressor Sialic Acid‐Binding Immunoglobulin‐Like Lectin‐15 for Cancer Immunotherapy
Q Wu, X Wei, F Chen, M Huang… - Angewandte Chemie …, 2023 - Wiley Online Library
The percentage of low response and adaptive resistance to current antibody‐based immune
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …
checkpoint blockade (ICB) therapy requires the development of novel immunotherapy …